氧化应激与胚胎的氧化还原调节

doi:10.11843/j.issn.0366-6964.2014.07.002

Abstract

Abstract:

Oxidative stress caused by elevated reactive oxygen species (ROS) is one of the predominant causes of both male and female infertility.Oxidative stress conditions cause either cell death or senescence by oxidation of cellular molecules including nucleic acid，proteins，and lipids.It is particularly important to minimize oxidative stress when in vitro fertilization is performed for the purpose of assisted reproduction.On the other hand，the beneficial roles of ROS，such as intracellular signaling，have become evident.The antithetical functions of ROS make it more difficult to overcome the problems caused by oxidative stress.This paper summarizes the research progress of the mechanism of action of ROS in oogenesis and in the process of embryonic development.

CLC Number:

S814.8

HU De-bao,ZHANG Bao-xiu,ZHANG Ye,ZHANG Ri-xin,FANG Nan-zhu，LI Zhong-shu. Oxidative Stress and Redox Regulation of Embryonic[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2014, 45(7): 1038-1043.

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References

［1］HALLIWELL B，GUTTERIDGE J M C.Free radicals in biology and medicine［M］.Oxford：Oxford University Press，1999:86-187.
［2］ITAHANA K，CAMPISI J，DIMRI G P.Mechanisms of cellular senescence in human and mouse cells［J］.Biogerontology，2004，5(1)：1-10.
［3］TREMELLEN K.Oxidative stress and male infertility：a clinical perspective［J］.Hum Reprod Update,2008,14(3):243-258.
［4］TURNER T T，LYSIAK J J.Oxidative stress：a common factor in testicular dysfunction［J］.J Androl，2008，29(5)：488-498.
［5］TAKAHASHI M.Oxidative stress and redox regulation on in vitro development of mammalian embryos［J］. J Reprod Dev，2012，58(1)：1-9.
［6］LANZAFAME F M，LA VIGNERA S，VICARI E，et al.Oxidative stress and medical antioxidant treatment in male infertility［J］.Reprod Biomed Online，2009，19(5)：638-659.
［7］GHARAGOZLOO P，AITKEN R J.The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy［J］.Hum Reprod，2011，26(7)：1628-1640.
［8］FINKEL T.Signal transduction by reactive oxygen species［J］.J Cell Biol，2011，194(1)：7-15.
［9］FUJIII J，TSUNODA S.Redox regulation of fertilisation and the spermatogenic process［J］.Asian J Androl，2011，13(3):420-423.
［10］OVERSTROM E W，DUBY R T，DOBRINSKY J，et al.Viability and oxidative metabolism of the bovine blastocyst［J］.Theriogenology，1992，37(1)：269.
［11］GUPTA S，SEKLHON L，KIM Y，et al.The role of oxidative stress and antioxidants in assisted reproduction［J］. Curr Women’s Health Rep，2010，6(3)：227-238.
［12］RHEE S G.H₂O₂，a necessary evil for cell signaling［J］.Science，2006，577(312)：1882-1883.
［13］JOHNSON J,CANNING J，KANEKO T，et al.Germline stem cells and follicular renewal in the postnatal mammalian ovary［J］.Nature，2004，428(6979)：145-150.
［14］MIAO Y L，KIKUCHI K，SUN Q Y.Oocyte aging：cellular and molecular changes，developmental potential and reversal possibility［J］.Hum Reprod Update，2009，15(5)：573-585.
［15］CHOI J K，AHN J I，PARK J H，et al.Derivation of developmentally competent oocytes by in vitro culture of preantral follicles retrieved from aged mice［J］.Fertil Steril，2011，95(4)：1487-1489.
［16］NODA Y，OTA K，SHIRASAWA T，et al.Copper/zinc superoxide dismutase insufficiency impairs progesterone secretion and fertility in female mice［J］.Biol Reprod，2012，86(1)：1-8.
［17］VAN BlERKOM J.Mitochondrial function in the human oocyte and embryo and their role in developmental competence［J］.Mitochondrion，2011，11(5)：797-813.
［18］LORD T，AITKEN R J.Oxidative stress and ageing of the post-ovulatory oocyte［J］.Reproduction，2013，146(6)：R217-R227.
［19］KUSHNIR V A，LUDAWAY T，RUSS R B，et al.Reproductive aging is associated with decreased mitochondrial abundance and altered structure in murine oocytes［J］.J Assist Reprod Genet，2012，29(7)：637-642.
［20］BAVISTER B D，SQUIRRELL J M.Mitochondrial distribution and function in oocytes and early embryos［J］.Hum Reprod，2000，15(2)：189-198.
［21］NASR-ESFAHANI M M，JOHNSON M H.The origin of reactive oxygen species in mouse embryos cultured in vitro［J］.Development，1991，113(2)：551-560.
［22］HENDRIKS W J A J，ELSON A，HARROCH S，et al.Protein tyrosine phosphatases in health and disease［J］.FEBS J，2013，280(2)：708-730.
［23］HENDRIKS W J，ELSON A，HARROCH S，et al.Protein tyrosine phosphatases：functional inferences from mouse models and human diseases［J］.FEBS J，2008，275(5)：816-830.
［24］PULIDO R，STOKER A W.PTPs emerge as PIPs：protein tyrosine phosphatases with lipid-phosphatase activities in human disease［J］.Hum Mol Genet，2013，22(R1)：R66-R76.
［25］NUMAJIRI N，TAKASAWA K，NISHIYA T，et al.On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN)［J］.Proc Natl Acad Sci，2011，108(25)：10349-10354.
［26］REDDY P，LIU L，ADHIKARI D，et al.Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool［J］.Science，2008，319(5863)：611-613.
［27］LI J，KAWAMURA K，CHENG Y，et al.Activation of dormant ovarian follicles to generate mature eggs［J］.Proc Natl Sci，2010，107(22)：10280-10284.
［28］BURON G J，HEMSPSTOCK J，JAUNIAUX E.Oxygen，early embryonic metabolism and free radical-mediated embryopathies［J］.Reprod Biomed Online，2003，6(1)：84-96.
［29］DENNERY P A.Oxidative stress in development：nature or nurture?［J］.Free Radic Biol Med，2010，49(7)：1147-1151.
［30］TSUNODA S，KIMURA N.Oxidative stress and redox regulation of gametogenesis，fertilization，and embryonic development［J］.Reprod Med Biol，2013：1-9.
［31］OH J S，HAN S J，CONTI M.Myt1，and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption［J］.J Cell Biol，2010，188(2)：199-207.
［32］HAN S J，VACCARI S，NEDACHI T，et al.Protein kinase B/Akt phosphorylation of PDE3A and its role in mammalian oocyte maturation［J］.EMBO J，2006，25(24)：5716-5725.
［33］KIMURA N，TSUNODA S，IUCHI Y，et al.Intrinsic oxidative stress causes either 2-cell arrest or cell death depending on developmental stage of the embryos from SOD1-deficient mice［J］.Mol Hum Reprod，2010，16(7)：441-451.
［34］NONOGAKI T，NODA Y，NARIMOTO K，et al.Protection from oxidative stress by thioredoxin and superoxide dismutase of mouse embryos fertilized in vitro［J］.Hum Reprod，1991，6(9)：1305-1310.
［35］NONOGAKI T，NODA Y，NARIMOTO K，et al.Effects of superoxide dismutase on mouse in vitro fertilization and embryo culture system［J］. J Assist Reprod Genet，1992，9(3)：274-280.
［36］MENG F G，ZHANG Z Y.Redox regulation of protein tyrosine phosphatase activity by hydroxyl radical［J］.Biochim Biophys Acta，2013，1834(1)：464-469.
［37］ZITO E，HANSEN H G，YEO G S H，et al.Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice［J］.Mol Cell，2012，48(1)：39-51.
［38］BAIN N T，MADAN P，BETTS D H.Elevated p66Shc is associated with intracellular redox imbalance in developmentally compromised bovine embryos［J］.Mol Reprod Dev，2013，80(1)：22-34.
［39］KAWAMURA Y，UCHIJIMA Y，HORIKE N，et al.Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest［J］.J Clin Invest，2010，120(8)：2817.

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Oxidative Stress and Redox Regulation of Embryonic

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